3-Phenylpropylamine → N-(3-Phenylpropyl)-3-(1H-imidazol-4-yl)propanamide

HRID 726224Notes

Reaction equation

HRID 726224 reaction equation
[C:1]1([CH2:7][CH2:8][CH2:9][NH2:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH:11]1[CH:15]=[C:14]([CH2:16][CH2:17][C:18](O)=[O:19])[N:13]=[CH:12]1>>[C:1]1([CH2:7][CH2:8][CH2:9][NH:10][C:18](=[O:19])[CH2:17][CH2:16][C:14]2[N:13]=[CH:12][NH:11][CH:15]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 162593-PhenylpropylamineHCID 178525356HCID 178525356, compound

Product 1

HCID 178520519N-(3-Phenylpropyl)-3-(1H-imidazol-4-yl)propanamide

Procedure

The preparation is carried out as in Example 1 with 3-phenylpropanamine and 3-(1H-imidazol-4-yl)propanoic acid, the acid being here added after the reaction of the amine component with N,N'-carbonyldiimidazole. The title compound is extracted from water with diethyl ether, purified by chromatography and recrystallized in the hydrogenmaleate form from ethanol/diethyl ether.

Workup

  1. additionthe acid being here added
  2. extractionThe title compound is extracted from water with diethyl ether
  3. custompurified by chromatography
  4. customrecrystallized in the hydrogenmaleate form from ethanol/diethyl ether

Sources & evidence

ORD record
ord-8b577d863b0544ae97215da9b9625b58
Source dataset
uspto-grants-1998_01
Patent number
US05708171

Reaction notes

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