HCID 178418361, compound → HCID 178507627, compound

HRID 726236Notes

Reaction equation

HRID 726236 reaction equation
[N+:1]([C:4]1[CH:22]=[CH:21][C:7]([CH2:8][NH:9][C:10](=[O:20])[O:11][CH2:12][CH2:13][CH2:14][C:15]2[N:16]=[CH:17][NH:18][CH:19]=2)=[CH:6][CH:5]=1)([O-])=O.[H][H]>CO.[Pd]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([CH2:8][NH:9][C:10](=[O:20])[O:11][CH2:12][CH2:13][CH2:14][C:15]2[N:16]=[CH:17][NH:18][CH:19]=2)=[CH:21][CH:22]=1

Participants

5

Reactant 2

HCID 178418361HCID 178418361, compoundHCID 178523024HCID 178523024, compound

Product 1

HCID 178507627HCID 178507627, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

2 mmol of the compound obtained in Example 67 are hydrogenated in 10 ml of methanol with 40 mg of palladium-on-charcoal (10%) with hydrogen. After absorption of the calculated amount of hydrogen, the solution is filtered, concentrated and purified by chromatography. The title compound obtained is crystallized in the hydrogenmaleate form from ethanol/diethyl ether.

Workup

  1. customAfter absorption of the calculated amount of hydrogen
  2. filtrationthe solution is filtered
  3. concentrationconcentrated
  4. custompurified by chromatography

Sources & evidence

ORD record
ord-af650cb9565e4908ad241bb862b51d36
Source dataset
uspto-grants-1998_01
Patent number
US05708171

Reaction notes

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