1-(2-Methoxyphenyl)piperazine → HCID 11463465, compound

Participants

Role	Name	HCID	Charge
Reactant	1-(2-Methoxyphenyl)piperazine	HCID 1346	—
Reactant	2-((2E)-4-chlorobut-2-en-1-yl)-2,3-dihydro-1H-isoindole-1,3-dione	HCID 5709374	—
Reactant	Trans-4-[4-(2-methyloxyphenyl)piperazinyl]-2-buten-1-yl-amine	HCID 19917461	—
Product	HCID 11463465	HCID 11463465	85.6%

Reaction Steps

Trans-4-[4-(2-methyloxyphenyl)piperazinyl]-2-buten-1-yl-amine: according to the method of Example 5, N-(trans-4-chloro-2-buten-1-yl)phthalimide was reacted with 1-(2-methyloxyphenyl)piperazine to obtain N-{4-[4-(2-methyloxy-phenyl)piperazinyl]-trans-2-buten-1-yl}phthalimide, which was then reacted with hydrazine hydrate. Yield: 85.6%, hydrochloride mp: 178-180° C.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08829001B2
Source dataset	uspto-grants-2014_09
ORD ID	ord-e3b2767709a643edab482f09656c61d0
Source note	uspto-grants-2014_09