2,5-Difluorobenzoyl chloride → HCID 54352620, compound

HRID 726361Notes

Reaction equation

HRID 726361 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:12](=[CH:13][CH:14]=1)[NH:11][C:10]1[CH2:9][CH2:8][CH:7]([N:15]([CH3:17])[CH3:16])[CH2:6][C:5]2=1.[F:18][C:19]1[CH:27]=[CH:26][C:25]([F:28])=[CH:24][C:20]=1[C:21](Cl)=[O:22]>>[F:18][C:19]1[CH:27]=[CH:26][C:25]([F:28])=[CH:24][C:20]=1[C:21]([NH:1][C:2]1[CH:3]=[C:4]2[C:12](=[CH:13][CH:14]=1)[NH:11][C:10]1[CH2:9][CH2:8][CH:7]([N:15]([CH3:17])[CH3:16])[CH2:6][C:5]2=1)=[O:22]

Participants

3

Reactant 2

HCID 5880822,5-Difluorobenzoyl chlorideHCID 226115606-amino-3-(dimethyl)amino-1,2,3,4-tetrahydro-9H-carbazole

Product 1

HCID 54352620HCID 54352620, compoundYield 78.3%

Procedure

Beginning with 10.4 mg (0.046 mMol) 6-amino-3-(dimethyl)amino-1,2,3,4-tetrahydro-9H-carbazole and 8.6 μL (0.051 mMol) 2,5-difluorobenzoyl chloride, 13.3 mg (78%) of the title compound were recovered as a beige solid.

Sources & evidence

ORD record
ord-05e5918058c24bdf815a2a4f5125ffea
Source dataset
uspto-grants-1998_01
Patent number
US05708187

Reaction notes

Loading…