反应详情

Concentrated sulfuric acid--water (1:1 v/v; 17 cm3) was added to a stirred suspension of 4-nitrobenzyl thioacetate (8.0 g, 37.9 mmol) in methanol (150 cm3) and the reactants were heated, under reflux, for 3 h. The cooled products were poured into water (1.0 dm3) and the resulting mixture was extracted with diethyl ether (2×400 cm3). The combined organic extracts were washed with water (2×200 cm3), dried (MgSO4) and evaporated under reduced pressure to give 4-nitrobenzyl mercaptan 17a as a pale yellow solid (6.31 g, 98%).

1. temperaturethe reactants were heated
2. temperatureunder reflux, for 3 h
3. extractionthe resulting mixture was extracted with diethyl ether (2×400 cm3)
4. washThe combined organic extracts were washed with water (2×200 cm3)
5. dry with materialdried (MgSO4)
6. customevaporated under reduced pressure