Citric Acid → HCID 57302818, compound

Participants

Reaction Steps

The compound (144 mg) obtained in the above (2) is dissolved in DMF (3 ml), and thereto is added 1N aqueous sodium hydroxide solution (698 μl) under ice-cooling, and the mixture is stirred for 1.5 hour. The pH value thereof is adjusted to pH 2 with 10% aqueous citric acid solution, and extracted three times with ethyl acetate. The extract is washed twice with a saturated brine, and dried over anhydrous magnesium sulfate. The desiccant is removed by filtration, and the filtrate is concentrated under reduced pressure to give the title compound (92 mg).

Provenance & Evidence