Morpholine → HCID 54294057, compound

Participants

Reaction Steps

1.4 g (3.1 mmol) of the ester prepared in (a), 190 mg (0.16 mmol) of tetrakis(triphenylphosphine)-palladium(O) and 50 ml of TEF were introduced into a three-necked flask under a nitrogen stream. 2.7 ml (31 mmol) of morpholine were then added dropwise and the mixture was stirred at room temperature for 2 hours. The reaction medium was evaporated to dryness, taken up in water, acidified to pH 1, and extracted with ethyl ether, the organic phase was decanted off, washed with water, dried over magnesium sulfate and evaporated. The residue obtained was triturated in 50 ml of dichloromethane, filtered and dried. 1.2 g (95%) of 4-[α-methoxyimino-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)acetamido]benzoic acid of melting point 208°-209° C. were recovered.

Provenance & Evidence