反应详情

15 g (0.06 mol) of 5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthylacetic acid, 150 ml of methanol and 1.6 ml of concentrated sulfuric acid were introduced into a round-bottomed flask. The mixture was heated at reflux for 4 hours, the reaction medium evaporated, taken up in water, and extracted with ethyl acetate. The organic phase was decanted off and dried over magnesium sulfate. 15.9 g (99%) of the expected ester of melting point 83°-85° C. were recovered.

1. temperatureThe mixture was heated
2. temperatureat reflux for 4 hours
3. customthe reaction medium evaporated
4. extractionextracted with ethyl acetate
5. customThe organic phase was decanted off
6. dry with materialdried over magnesium sulfate
7. custom15.9 g (99%) of the expected ester of melting point 83°-85° C. were recovered