Methyl 1-methyl-5-nitro-1H-pyrrole-2-carboxylate → Methyl 5-amino-1-methyl-1H-pyrrole-2-carboxylate

Participants

Reaction Steps

1.31 g (7.4 mmol) of methyl N-methyl-5-nitro-2-pyrrolecarboxylate, 400 mg of palladium on carbon (10%) and 50 ml of methanol were introduced into a reactor. The mixture was hydrogenated at room temperature and at a pressure of 7 bar for 2 hours. The catalyst was filtered, washed twice with 25 ml of methanol and the filtrates evaporated. 1.1 g (100%) of the expected amine was recovered in the form of a dark red oil.

Provenance & Evidence