反应详情

温度

75 °C

A mixture of methyl 2-((6-methoxy-5-nitropyridin-3-yl)methylthio)acetate (1.0 mmol, 0.27 g) and sodium carbonate (0.3 g) in 150 mL of distilled water was heated at 75° C. for 6 hrs. The mixture was evaporated in vacuo to give 2-((6-methoxy-5-nitropyridin-3-yl)methylthio)acetic acid. Yield 90%; m.p. 249-251° C. (dec.) 1H-NMR (D2O) δ: 3.04 (s, 2H, CH2), 3.74 (s, 2H, CH2), 4.01 (s, 3H, OCH3), 8.28 (d, J=1.0 Hz, 1H, Ar—H), 8.43 (d, J=1.0 Hz, 1H, Ar—H); 13C-NMR (D2O) 6; 31.50, 35.93, 55.02, 128.19, 133.18, 136.76, 151.83, 155.53, 177.29; DEPT-135 (O2O): δ 31.50 (CH2), 35.93 (CH2), 55.02 (CH3) 136.76 (CH), 151.83 (CH); HR-MS (ESI+) m/z 257.0206 [M+H]+, C9H10N2O6S requires 258.0310.

1. customThe mixture was evaporated in vacuo