p-Toluenesulfonic acid → HCID 19706374, compound

Participants

Reaction Steps

First, 8 g of 4-[4-(2,3-difluorophenyl)-3-cyclohexenyl]cyclohexanone ethylene ketal, 0.5 g of p-toluenesufonic acid, 40 ml of dioxane, and 110 ml of water were placed in a 300 ml flask. The mixture was stirred under reflux for 5 hours. The reaction mixture was extracted with ether. The ether layer was washed with water and dried over anhydrous sodium sulfate. Then, the solvent was distilled away. The residue was recrystallized from hexane to obtain 5.65 g of 4-[4-(2,3-difluorophenyl)-3-cyclohexenyl]cyclohexanone (Y: 81.4%). The compound thus obtained had a purity of 98.4% by GC.

Provenance & Evidence