Sulfuric Acid → HCID 23196286, compound

Participants

Reaction Steps

A mixture of 100 microliters of aqueous glutaric dialdehyde (content about 25%), 300 microliters of diluted sulfuric acid and 1 ml of tetrahydrofuran/methanol 1:1 is added with stirring at ice bath temperature to 37 mg of (6-amino-2,3-dioxo-1,2,3,4-tetrahydrobenzo[f]quinoxalin-4-yl)-methanephosphonic acid diethyl ester in 2 ml of tetrahydrofuran z.A., to which 13 mg of sodium borohydride was added. Then, another 10 mg of sodium boronate is added and worked up for 1 more hour. The mixture is neutralized and extracted with ethyl acetate. After chromatography with a little silica gel, 16 mg of product is obtained.

Provenance & Evidence