Sodium borohydride → HCID 19706768, compound

Participants

Reaction Steps

A stirred, ice-cooled solution of 2,2-difluoro-3-ethyl-3-trimethylsilyloxy-pentanal (1.45 g, 6.08 mmol) in THF (5 ml) and ethanol (15 ml) was treated with sodium borohydride (2.76 mg, 7.30 mmol). After 30 minutes the reaction mixture was partitioned between ethyl acetate and water, and the organic layer was washed with brine, dried over MgSO4 and concentrated. Flash chromatography (50 g silica gel; 10% EtOac in petroleum ether as eluant) afforded the title compound as a colourless oil, δ 0.15 (s, 9H), 1.36 (t, 6H), 2.48 (m, 1H), 3.93 (m, 2H).

Provenance & Evidence