HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,3-Dibromobenzene → 3-Bromo-4'-chloro-biphenyl
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,3-Dibromobenzene | HCID 7927 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 4-Chlorophenylboronic acid | HCID 74299 | — |
| Catalyst | Tetrakis(triphenylphosphine)palladium | HCID 11979704 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 3-Bromo-4'-chloro-biphenyl | HCID 2756874 | — |
Reaction Steps
This compound is prepared in a manner analogous to that of Step D of Example 4, using 6.9 grams (0.044 mole) of 4-chlorophenylboronic acid (commercially available), 25.0 grams (0.100 mole) of 1,3-dibromobenzene, 0.2 gram (catalyst) of tetrakis(triphenylphosphine)palladium(O), 75 mL of aqueous 2M sodium carbonate, and 75 mL of toluene, yielding 3-(4-chlorophenyl)phenyl bromide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05710157 |
| Source dataset | uspto-grants-1998_01 |
| ORD ID | ord-35928e09b0514cfaa491597f46e1284f |
| Source note | uspto-grants-1998_01 |