HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 2-Amino-3-cyano-4-methyl-5-[3-(4-chlorophenyl)phenyl]pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Amino-5-bromo-4-methylnicotinonitrile | HCID 11321806 | — |
| Reactant | [3-(4-Chlorophenyl)phenyl]boronic acid | HCID 23005392 | — |
| Catalyst | Tetrakis(triphenylphosphine)palladium | HCID 11979704 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 2-Amino-3-cyano-4-methyl-5-[3-(4-chlorophenyl)phenyl]pyridine | HCID 19707200 | — |
Reaction Steps
This compound is prepared in a manner analogous to that of Step D of 5 Example 4, using 1.7 grams (0.008 mole) of 2-amino-5-bromo-3-cyano-4-methylpyridine, 2.9 grams (0.012 mole) of 3-(4-chlorophenyl)phenylboronic acid, 4.3 grams (0.031 mole) of potassium carbonate and 0.3 gram of tetrakis(triphenylphosphine)palladium(O) in 150 mL of toluene, yielding 2-amino-3-cyano-4-methyl-5-[3-(4-chlorophenyl)phenyl]pyridine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05710157 |
| Source dataset | uspto-grants-1998_01 |
| ORD ID | ord-3165c6962a2043e9a76f463c3a8b6e5b |
| Source note | uspto-grants-1998_01 |