Trimethyl phosphite → HCID 53679805, compound

Participants

Reaction Steps

A mixture of the obtained 3-bromomethyl-2-methylquinoline (0.25 g, 1.0 mmol) and trimethyl phosphite (0.4 ml, 3.2 mmol) was refluxed in toluene (10 ml) for 16 hours. The reaction mixture was then concentrated in vacuo and the residue was flash chromatographed on silica gel. Elution with ethyl acetate afforded 0.28 g of 3-(dimethylphosphonomethyl)-2-methylquinoline.

Provenance & Evidence