Benzoyl Peroxide → HCID 53755250, compound

Participants

Reaction Steps

A solution of the obtained 3-(dimethylphosphonomethyl)-2-methylquinoline (0.28 g, 1.0 mmol) in carbon tetrachloride (20 ml) was treated with benzoylperoxide (50 mg) followed by N-bromosuccinimide (0.20 g, 1.1 mmol). The reaction mixture was refluxed for 4 hours, filtered and concentrated in vacuo. The residue was flash chromatographed on silica gel with ethyl acetate as the eluent to give 0.21 g of 2-bromomethyl-3-(dimethylphosphonomethyl)quinoline.

Provenance & Evidence