Trimethyl phosphite → HCID 54362131, compound

Participants

Reaction Steps

A mixture of 2,3-di(bromomethyl)quinoline (0.50 g, 1.4 mmol) and trimethyl phosphite (0.18 ml, 1.4 mmol) was refluxed in toluene for 4 hours. The reaction mixture was then concentrated in vacuo and the residue was flash chromatographed on silica gel. Elution with ethyl acetate afforded 0.35 g of 3-bromomethyl-2-(dimethylphosphonomethyl)quinoline.

Provenance & Evidence