N-bromobutanimide → HCID 19706754, compound

Participants

Reaction Steps

To a solution of 6-chloro-2,3-dimethylquinoline (2.0 g, 10.5 mmol) in carbon tetrachloride (80 ml) benzoyl peroxide (100 mg) and N-bromosuccinimide (3.7 g, 21.0 mmol) were added. The reaction mixture was refluxed for 4 hours, and then cooled to room temperature. The precipitate was removed by filtration and the filtrate was evaporated in vacuo. The residue was flash chromatographed on silica gel with ethyl acetate/petroleum ether as the eluent to give 0.90 g 3-bromomethyl-6-chloro-2-methylquinoline.

Provenance & Evidence