Trimethyl phosphite → HCID 54514340, compound

Participants

Reaction Steps

A mixture of 3-bromomethyl-6-chloro-2-methylquinoline (0.85 g, 3.0 mmol) and trimethyl phosphite (1.2 ml, 9.6 mmol) was refluxed in toluene (20 ml) for 16 hours. The reaction mixture was then concentrated in vacuo and the residue was flash chromatographed on silica gel. Elution with ethyl acetate afforded 0.90 g of 6-chloro-3-(dimethylphosphonomethyl)-2-methylquinoline.

Provenance & Evidence