Benzoyl Peroxide → HCID 53685615, compound

Participants

Reaction Steps

A solution of 6-chloro-3-(dimethylphosphonomethyl)-2-methylquinoline (0.85 g, 2.7 mmol) in carbon tetrachloride (40 ml) was treated with benzoyl peroxide (100 mg) followed by N-bromosuccinimide (0.50 g, 2.8 mmol). The reaction mixture was refluxed for 4 hours, filtered and concentrated in vacuo. The residue was flash chromatographed on silica gel with ethyl acetate as the eluent to give 0.75 g of 2-bromomethyl-6-chloro-3-(dimethylphosphonomethyl)quinoline.

Provenance & Evidence