HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Iodide → HCID 54141905, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | Phosphonic acid, [(2-chloro-6,7-dimethyl-3-quinolinyl)methyl]-, diethyl ester | HCID 54299050 | — |
| Solvent | Methyl Ethyl Ketone | HCID 6569 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 54141905 | HCID 54141905 | 55.2% |
Reaction Steps
2-Chloro-3-diethylphosphonomethyl-6,7-dimethylquinoline (0.40 g, 1.17 mmol), prepared as described in Example 4 was dissolved in 2-butanone (20 ml) and treated with sodium iodide (0.39 g, 2.6 mmol) and p-toluenesulfonic acid (0.11 g, 0.58 mmol). The mixture was refluxed for 10 hours. Ethyl acetate and saturated sodium hydrogen carbonate were added. The organic phase was separated and filtered through a pad of silica gel. Evaporation of solvents gave 0.28 g of 3-diethylphosphonomethyl-6,7-dimethyl-2-iodoquinoline.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05710139 |
| Source dataset | uspto-grants-1998_01 |
| ORD ID | ord-86ac58cb62634e7b8da6395d96e67a65 |
| Source note | uspto-grants-1998_01 |