HCID 54189282, compound → HCID 44289198, compound

Participants

Reaction Steps

Methyl(R)-α-t-butoxycarbonylamino-7-chloro-3-diethylphosphonomethyl-2-quinolinepropionate (0.23 g, 0.45 mmol), prepared as described in example 5, was refluxed in 6N hydrochloric acid (10 ml) for 6 hours. The mixture was concentrated in vacuo and 100 mg of (R)-α-amino-7-chloro-3-(phosphonomethyl)-2-quinolinepropanoic acid was precipitated from water. 1H NMR(D2O, 400 MHz): δ 3.18 (d, 2H, CH2 --P), 3.58 (m, 2H, CH2), 4.38 (m, 1H, CH), 7.12 (d, 1H, ArH), 7.47 (d, 1H, ArH), 7.53 (s, 1H, ArH), 8.42 (d, 1H, ArH).

Provenance & Evidence