Tetrahydrofuran → HCID 19706756, compound

Participants

Reaction Steps

A mixture of 2-nitro-4,5-dimethoxybenzaldehyde (5.28 g, 25 mmol) and Raney-nickel in THF (100 ml) was hydrogenated until three equivalents of hydrogen had been consumed. The mixture was filtered through Celite. Ethyl acetoacetate (3.2 ml, 25 mmol) and piperidine (12 drops) were added and the solution was refluxed for 4 h and concentrated. The solid residue was recrystallized from MeOH to give 3.89 g ethyl 6,7-dimethoxy-2-methylquinoline-3-carboxylic acid.

Provenance & Evidence