Ethyl Acetate → HCID 19706721, compound

Participants

Reaction Steps

A solution of 6,7-dimethoxy-2-methylquinoline-3-carboxylic acid ethyl ester (2.83 g, 10.3 mmol) in dry THF (75 ml) was added dropwise over 20 min to a stirred, ice-cooled suspension of lithium aluminiumhydride (0.39 g, 10.3 mmol) in dry THF (50 ml). The mixture was allowed to come to room temperature over 2 h and the excess lithium aluminiumhydride was decomposed by sequential careful addition of ethyl acetate, acetone and 2M NaOH. The mixture was filtered and the white gummy material was extracted twice with acetone. The filtrate and the extracts were combined and concentrated to give 2.31 g of 6,7-dimethoxy-2-methylquinoline-3-methanol.

Provenance & Evidence