反应详情

A mixture of 2-bromo-3-bromomethyl-7-chloro-6-methylquinoline (4.2 g, 12 mmol), toluene (50 ml) and triethylphosphite (4.2 ml) was refluxed for 20 h. After cooling the solution was concentrated in vacuum and the product precipitated by the addition of hexane. The crystals were filtered off, washed with hexane and dried in vacuo to give 4.5 g of 2-bromo-7-chloro-3-diethylphosphonomethyl-6-methylquinoline.

1. temperaturewas refluxed for 20 h
2. temperatureAfter cooling the solution
3. concentrationwas concentrated in vacuum
4. customthe product precipitated by the addition of hexane
5. filtrationThe crystals were filtered off
6. washwashed with hexane
7. customdried in vacuo