Water → HCID 22881398, compound

Participants

Reaction Steps

Trichloromethyl chloroformate (0.18 mL, 1.5 mmol) was added to a 0° C. solution of (R)-4-[1-(3-cyclopentyloxy-4-methoxyphenyl)-2-(4-pyridyl)ethyl]benzaldehyde oxime from Example 3 (425 mg, 1.0 mmol) in acetonitrile (4 mL). The reaction mixture was stirred at room temperature for 1 hour before water was added. The mixture was then extracted with EtOAc. The organic phase was washed with 5% aqueous NaHCO3, water and brine, dried (MgSO4) and evaporated to afford the title compound as an off-white solid (350 mg, 86%).

Provenance & Evidence