HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalyl chloride → [(Z)-1-[4-(2-Biphenylylcarbonylamino)benzoyl]-4,4-difluoro-2,3,4,5-tetrahydro-1H-1-benzazepine-5-ylidene]acetic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | o-Phenylbenzoic acid | HCID 70357 | — |
| Reactant | methyl (Z)-[1-(4-aminobenzoyl)-4,4-difluoro-2,3,4,5-tetrahydro-1H-1-benzazepin-5-ylidene]acetate | HCID 10809276 | — |
| Product | [(Z)-1-[4-(2-Biphenylylcarbonylamino)benzoyl]-4,4-difluoro-2,3,4,5-tetrahydro-1H-1-benzazepine-5-ylidene]acetic acid methyl ester | HCID 10602784 | 95.4% |
Reaction Steps
Using 396 mg of o-phenylbenzoic acid, 0.290 ml of oxalyl chloride and 620 mg of methyl (Z)-[1-(4-aminobenzoyl)4,4-difluoro-2,3,4,5-tetrahydro-1H-1-benzazepin-5ylidene]acetate, a similar procedure as in Reference Example 8 was repeated to obtain 878 mg of methyl (Z)-[4,4-difluoro-1-[4-(2-phenylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepin-5-ylidene]acetate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05710150 |
| Source dataset | uspto-grants-1998_01 |
| ORD ID | ord-b90bfd45316e4736b6fae03372eaa6f0 |
| Source note | uspto-grants-1998_01 |