HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalyl chloride → methyl (Z)-[4,4-difluoro-1-[4-[2-(3methylphenyl)benzoylamino]benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepin-5-ylidene]acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 2-(3-methylphenyl)benzoic Acid | HCID 4321321 | — |
| Reactant | methyl (Z)-[1-(4-aminobenzoyl)-4,4-difluoro-2,3,4,5-tetrahydro-1H-1-benzazepin-5-ylidene]acetate | HCID 10809276 | — |
| Product | methyl (Z)-[4,4-difluoro-1-[4-[2-(3methylphenyl)benzoylamino]benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepin-5-ylidene]acetate | HCID 86751967 | 90.9% |
Reaction Steps
Using 277 mg of 2-(3-methylphenyl)benzoic acid, 0.127 ml of oxalyl chloride and 180 mg of methyl (Z)-[1-(4-aminobenzoyl)-4,4-difluoro-2,3,4,5-tetrahydro-1H-1-benzazepin-5-ylidene]acetate, a similar procedure as in Reference Example 8 was repeated to obtain 249 mg of methyl (Z)-[4,4-difluoro-1-[4-[2-(3methylphenyl)benzoylamino]benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepin-5-ylidene]acetate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05710150 |
| Source dataset | uspto-grants-1998_01 |
| ORD ID | ord-969decaf9656472890dbddcf8d6019a2 |
| Source note | uspto-grants-1998_01 |