HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 3-[4-Cyanobenzyl]aminobenzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | 3-Aminobenzoic Acid | HCID 7419 | — |
| Reactant | 4-Cyanobenzaldehyde | HCID 66042 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 3-[4-Cyanobenzyl]aminobenzoic acid | HCID 19707399 | 75.3% |
Reaction Steps
4-cyanobenzaldehyde (0.65 g; 5 mmoles), 3-aminobenzoic acid (0.68 g; 5 mmoles) and sodiumcyanoborohydride (0.35 g; 5 mmols) were stirred in N,N-dimethylformamide (25 ml) containing 1% acetic acid at room temperature for 2 hrs. The product was precipitated out by addition of water. The solid was filtered and dried in vacuo to give 0.95 g white solid. FAB-MS: MH+ =253.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05710166 |
| Source dataset | uspto-grants-1998_01 |
| ORD ID | ord-1606ef0ee9e846559855b749621dffd0 |
| Source note | uspto-grants-1998_01 |