2-(((3-(Trifluoromethyl)phenyl)methyl)sulfonyl)acetonitrile → HCID 67582727, compound

HRID 726740Notes

Reaction equation

HRID 726740 reaction equation
[NH2:1][C:2]([C:4]1[S:5][C:6]([CH:9]=O)=[CH:7][CH:8]=1)=[O:3].[F:11][C:12]([F:27])([F:26])[C:13]1[CH:14]=[C:15]([CH:23]=[CH:24][CH:25]=1)[CH2:16][S:17]([CH2:20][C:21]#[N:22])(=[O:19])=[O:18]>>[NH2:1][C:2]([C:4]1[S:5][C:6](/[CH:9]=[C:20](/[S:17]([CH2:16][C:15]2[CH:23]=[CH:24][CH:25]=[C:13]([C:12]([F:27])([F:11])[F:26])[CH:14]=2)(=[O:19])=[O:18])\[C:21]#[N:22])=[CH:7][CH:8]=1)=[O:3]

Participants

3

Reactant 2

HCID 27824342-(((3-(Trifluoromethyl)phenyl)methyl)sulfonyl)acetonitrileHCID 122800175-Formylthiophene-2-carboxamide

Product 1

HCID 67582727HCID 67582727, compound

Procedure

Reaction of 2-aminocarbonylthiophen-5-carboxaldehyde and 3-trifluoromethylbenzylsulfonylacetonitrile as in Example 1 gave (E)-3-(2-aminocarbonylthien-5-yl)-2-[3-(trifluoromethyl)benzylsulfonyl]acrylonitrile

Sources & evidence

ORD record
ord-03b157c7f36645f3a6dff6056b7bf27e
Source dataset
uspto-grants-1998_01
Patent number
US05710173

Reaction notes

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