反应详情

To a solution of crude 2-(3-cyclopentyloxy-4-methoxyphenyl)ethylamine (0.5 g, 2.1 mmol) in pyridine (1.8 mL) under an argon atmosphere was added acetic anhydride (1.25 mL). The resulting solution was stirred at room temperature for 16 h and then concentrated under reduced pressure. The residue was dissolved in methylene chloride, washed with water and dried (sodium sulfate). The solvent was removed in vacuo, the residue was purified by flash chromatography, eluting with 4% methanol/ether, and then triturated with ether to provide the acetamide: m.p. 87°-88° C.

1. concentrationconcentrated under reduced pressure
2. dissolutionThe residue was dissolved in methylene chloride
3. washwashed with water
4. dry with materialdried (sodium sulfate)
5. customThe solvent was removed in vacuo
6. customthe residue was purified by flash chromatography
7. washeluting with 4% methanol/ether
8. customtriturated with ether