Ethylene Glycol → [3-(2-Hydroxyethoxy)-3-oxopropyl]phenylphosphinic acid

HRID 726833Notes

Reaction equation

HRID 726833 reaction equation
[OH:1][P:2]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)([CH2:4][CH2:5][C:6]([OH:8])=[O:7])=[O:3].[CH2:15](O)[CH2:16][OH:17]>>[OH:3][P:2]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)([CH2:4][CH2:5][C:6]([O:8][CH2:15][CH2:16][OH:17])=[O:7])=[O:1]

Participants

3

Reactant 2

HCID 174Ethylene GlycolHCID 112873403-(Hydroxyphenylphosphinyl)propanoic acid2×

Product 1

HCID 69477555[3-(2-Hydroxyethoxy)-3-oxopropyl]phenylphosphinic acid

Procedure

Except that the recrystallization-purified 3-[hydroxy(phenyl)phosphinyl]propionic acid obtained in Comparative Example 3 was used in lieu of the rinse-purified 3-[hydroxy(phenyl)phosphinyl]propionic acid, the procedure of Comparative Example 4 was repeated to provide 102.81 g of an ethylene glycol solution of hydroxyethyl 3-[hydroxy(phenyl)phosphinyl]propionate.

Sources & evidence

ORD record
ord-be29f29a405c4c88b9a9bcaf85f021c8
Source dataset
uspto-grants-1998_01
Patent number
US05710308

Reaction notes

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