Benzoyl Peroxide → 2-(2-Bromomethylphenyl)-3-fluoromethoxyacrylic acid methyl ester

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Reaction Steps

Preparation of ##STR7## 11.75 g of N-bromosuccinimide are added in several small portions, under reflux, to a solution of 14.75 g of 3-fluoromethoxy-2-(o-tolyl)-acrylic acid methyl ester and 0.53 g of dibenzoyl peroxide in 90 ml of carbon tetrachloride and then the mixture is refluxed for a further 0.5 hour. The suspension is cooled to room temperature, filtered and concentrated to dryness by evaporation. Chromatography on silica gel with hexane/ethyl acetate (6:1) yields pure 2-(2-bromomethylphenyl)-3-fluoromethoxy-acrylic acid methyl ester; m.p. 73°-76° C.

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