Benzoyl Peroxide → HCID 53901982, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 5.1 g of o-tolylglyoxalic acid methyl ester O-difluoromethyl oxime, 0.16 g of dibenzoyl peroxide and 40 ml of carbon tetrachloride is heated to reflux. With radiation from a lamp, 3.55 g of N-bromosuccinimide are added thereto in several small portions, the mixture is left to react under reflux for 30 minutes and is then cooled to 20° C. and the succinimide which precipitates is removed by filtration. The filtrate is concentrated by evaporation; after chromatography on silica gel with hexane/ethyl acetate (6:1) pure 2-(bromomethyl)-phenylglyoxalic acid methyl ester O-difluoromethyl oxime is obtained in the form of a pale yellow oil.

Provenance & Evidence