Pyridine → HCID 54454033, compound

Participants

Reaction Steps

To a solution of 70 from Example 69, being 60.2 mg in 4 ml methylene chloride and 200 ml pyridine was added 15 mg DMAP (4-dimethylaminopyridine) followed by 68.66 mg pivaloyl chloride, i.e., trimethyl acetyl chloride. After stirring for 24 hours, the reaction mixture was diluted with ethyl acetate, washed with water, then aqueous sodium carbonate and brine. The organic layer was dried, concentrated to a residue, which was purified by preparative chromatography on silica gel using 3:1 chloroform/acetone as eluant to yield pure title compound 71 Proton NMR confirmed the assigned structure.

Provenance & Evidence