tert-Butyl isocyanate → HCID 22881410, compound

Participants

Reaction Steps

To a solution of 70, 51 mg in 4 ml methylene chloride was added DBU (200 microliters) followed by 63.65 mg. t-butylisocyanate. After stirring the mixture for 48 hours at room temperature, the reaction mixture was diluted with ethyl acetate, the organic layer washed with water, brine, dried and concentrated to a residue which was purified by preparative chromatography over silica gel using 3:1 CHCl3 /acetone to yield pure title compound 72.

Provenance & Evidence