ethyl 3,3-dimethyl-2-oxobutanoate → HCID 86751969, compound

HRID 726868Notes

Reaction equation

HRID 726868 reaction equation
[CH3:1][C:2]([CH3:11])([CH3:10])[C:3](=O)[C:4]([O:6]CC)=O.[C:12]1([C@H:18]([NH2:20])[CH3:19])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>C(Cl)(Cl)Cl>[CH3:11][C:2]([CH3:1])([CH3:10])[C:3](=[N:20][C@@H:18]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[CH3:19])[C:4]([NH:20][C@@H:18]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[CH3:19])=[O:6]

Participants

4

Reactant 2

HCID 220085ethyl 3,3-dimethyl-2-oxobutanoateHCID 6431891-Phenethylamine, (+)-

Product 1

HCID 86751969HCID 86751969, compoundYield 47%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

The procedure described under h) was carried out using 15 g of ethyl trimethyl-pyruvate and 50 g of (R)-1-phenylethylamine. There were isolated 14.9 g of (47%) of (R)-3,3-dimethyl-N-[(R)-1-phenylethyl]-2-(1-phenylethylimino)-butyramide of melting point 95°-96° C. [α]=+59.6 (c=1.0, CHCl3).

Sources & evidence

ORD record
ord-a5438db2280a4b2cba64b96aee30d8ec
Source dataset
uspto-grants-1998_01
Patent number
US05710322

Reaction notes

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