HCID 54494529, compound → (2S)-2-Amino-N,3,3-trimethylbutanamide

Participants

Reaction Steps

A solution of 12.4 g (50 mmol) of (S)-3,3,N-trimethyl-2-[(S)-1-phenylethylamino]-butyramide in 206 ml of methanol was hydrogenated in a 380 ml autoclave in the presence of 1.2 g of 5 percent Pd/C at 50° C. and under a pressure of 4 bar for 6 hours. After pressure release the catalyst was filtered off and the filtrate was evaporated to dryness. There were obtained 7.1 g (98.5%) of (S)-N-methyl-tert-leucinamide as white crystals, 99.2% e.e.

Provenance & Evidence