HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2S)-2-Amino-N,3,3-trimethylbutanamide → L-tert-Leucine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2S)-2-Amino-N,3,3-trimethylbutanamide | HCID 445856 | — |
| Reactant | Acetate-hydrochloric acid | HCID 22641269 | — |
| Product | L-tert-Leucine | HCID 164608 | 41% |
Reaction Steps
A solution of (S)-N-methyl-tert-leucinamide in 100 ml of a 6N solution of HCl/CH3COOH (1:1) was heated under reflux for 14 days. Then, the mixture was evaporated, the residue was chromatographic over AMBERLITE. Evaporation and drying gave 750 mg (41%) of (S)-tert-leucine, [α]=+6.2 (c=1.62, 5N HCl), 97% e.e.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05710322 |
| Source dataset | uspto-grants-1998_01 |
| ORD ID | ord-b9447329890e458a93cc64d9374755eb |
| Source note | uspto-grants-1998_01 |