HCID 19352271, compound → HCID 19352273, compound

HRID 726891Notes

Reaction equation

HRID 726891 reaction equation
[CH3:1][O:2][C:3]([NH:5][C:6]1[C:7](=[O:21])[O:8][CH:9]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([O:17][CH3:18])[C:12]=2[O:19][CH3:20])[CH:10]=1)=[O:4]>O=O>[CH3:1][O:2][C:3]([NH:5][CH:6]([CH2:10][CH2:9][C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([O:17][CH3:18])[C:12]=1[O:19][CH3:20])[C:7]([OH:21])=[O:8])=[O:4]

Participants

3

Reactant 1

HCID 19352271HCID 19352271, compound

Product 1

HCID 19352273HCID 19352273, compound

Reagents, catalysts & solvents 1

HCID 977OxygenSolvent

Procedure

A solution of 3-methoxycarbonylamino-5-(2,3-dimethoxyphenyl)-2,5-dihydrofuran-2-one (500 mg, 1.7 mmoles) in oxygen free methanol (0.25M) is placed into a Parr hydrogenator, the catalyst (RR)-EtDiPhos(COD)OTs (1.5 μmoles) is added and the mixture is stirred for 1.5 hr at room temperature under hydrogen pressure (30 psi).

Sources & evidence

ORD record
ord-92508f7aa8c04f72a94a024fac702347
Source dataset
uspto-grants-1998_01
Patent number
US05710336

Reaction notes

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