HCID 86747903, compound → HCID 86747902, compound

HRID 726900Notes

Reaction equation

HRID 726900 reaction equation
[C:1]([O:5][C:6]([NH:8][CH:9]([CH:17]=[CH:18][CH2:19][O:20]CC1C=CC=CC=1)[C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])=[O:7])([CH3:4])([CH3:3])[CH3:2]>C(O)C.[Pd]>[C:1]([O:5][C:6]([NH:8][CH:9]([CH:17]=[CH:18][CH2:19][OH:20])[C:10]([O:12][C:13]([CH3:15])([CH3:14])[CH3:16])=[O:11])=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 1

HCID 86747903HCID 86747903, compound

Product 1

HCID 86747902HCID 86747902, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

Mix 2-(N-t-butyloxycarbonylamino)-5-(O-benzyloxy)-3-pentenoic acid, t-butyl ester (2.0 g, 5.3 mmol) and 10% palladium/carbon (0.5 g) in 95% ethanol (40 mL). Hydrogenate at room temperature at atmospheric pressure. Filter and evaporate the filtrate in vacuo to give 2-(N-t-butyloxycarbonylamino)-5-hydroxy-3-pentenoic acid, t-butyl ester.

Workup

  1. customat room temperature
  2. filtrationFilter
  3. customevaporate the filtrate in vacuo

Sources & evidence

ORD record
ord-4d00dd83b6e8436bb469db90bd8e049f
Source dataset
uspto-grants-1998_01
Patent number
US05710324

Reaction notes

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