反应详情

Mix 5-[(2-(carbethoxyhydrazino)-ethyl)]-hydantoin (2.3 g, 10 mmol), barium hydroxide octahydrate (18.15 g, 10 mmol) and water (55 mL). Reflux for 12 hours, remove the white solid by filtration, extract the filter cake with boiling water (25 ml) and finally wash with hot water (25 mL). Combine the filtrate and washings, treat with ammonium carbonate (5.7 g) and heat with stirring. Filter off the barium carbonate, wash the filter cake with hot water and evaporate the filtrate and washings in vacuo to give 2-amino-4-hydrazino-butanoic acid.

1. temperatureReflux for 12 hours
2. customremove the white solid
3. filtrationby filtration
4. extractionextract the filter cake with boiling water (25 ml)
5. washfinally wash with hot water (25 mL)
6. additionCombine the filtrate and washings, treat with ammonium carbonate (5.7 g)
7. temperatureheat
8. filtrationFilter off the barium carbonate
9. washwash the filter cake with hot water
10. customevaporate the filtrate and washings in vacuo