Barium hydroxide, octahydrate → HCID 19708153, compound

HRID 726908Notes

Reaction equation

HRID 726908 reaction equation
C([NH:6][NH:7][CH2:8][CH2:9][CH2:10][CH:11]1[NH:15]C(=O)N[C:12]1=[O:17])(OCC)=O.[OH2:18].O.O.O.O.O.O.O.[OH-].[Ba+2].[OH-]>O>[NH2:15][CH:11]([CH2:10][CH2:9][CH2:8][NH:7][NH2:6])[C:12]([OH:17])=[O:18]

Participants

4

Reactant 2

HCID 17749109Barium hydroxide, octahydrateHCID 67827772HCID 67827772, compound

Product 1

HCID 19708153HCID 19708153, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Mix 5-[3-(carbethoxyhydrazino)-propyl]-hydantoin (2.44 g, 10 mmol), barium hydroxide octahydrate (18.15 g, 10 mmol) and water (55 mL). Reflux for 12 hours, remove the white solid by filtration and extract the filter cake with boiling water (25 ml) and finally wash with hot water (25 mL). Combine the filtrate and washings, treat with ammonium carbonate (5.7 g) and heat with stirring. Filter off the barium carbonate, wash the filter cake with hot water and evaporate the filtrate and washings in vacuo to give 2-amino-5-hydrazino- pentanoic acid.

Workup

  1. temperatureReflux for 12 hours
  2. customremove the white solid
  3. filtrationby filtration
  4. extractionextract the filter cake with boiling water (25 ml)
  5. washfinally wash with hot water (25 mL)
  6. additionCombine the filtrate and washings, treat with ammonium carbonate (5.7 g)
  7. temperatureheat
  8. filtrationFilter off the barium carbonate
  9. washwash the filter cake with hot water
  10. customevaporate the filtrate and washings in vacuo

Sources & evidence

ORD record
ord-cae7df32282146e7a53622a0b8e06b2e
Source dataset
uspto-grants-1998_01
Patent number
US05710324

Reaction notes

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