Hydrochloric Acid → Benzenesulfonamide, 3-nitro-N-phenyl-

Participants

Reaction Steps

To a solution of 3-nitrobenzenesulfonyl chloride (3.08 g, 13.9 mmol) in 28 mL of dichloromethane was added triethylamine (3.88 mL, 27.8 mmol) and aniline (1.39 mL. 15.3 mmol). After 16 hours, the reaction was poured into ethyl acetate and 10% HCl solution, then washed with brine, dried (MgSO4) and concentrated in vacuo to provide the crude product. Purification by chromatography on silica gel (25-50% CH2Cl2 /hexane, then 5% MeOH/CH2Cl2) provided 1.68 g of the desired product as an off-white solid.

Provenance & Evidence