HCID 54463660, compound → HCID 10656658, compound

HRID 726972Notes

Reaction equation

HRID 726972 reaction equation
[CH2:1]([O:3][C:4](=[O:16])[C:5](=[C:8]1[CH2:14][N:13]2[CH2:15][CH:9]1[CH2:10][CH2:11][CH2:12]2)[C:6]#[N:7])[CH3:2].[H][H]>[Pd].C(O)C>[CH2:1]([O:3][C:4](=[O:16])[CH:5]([CH:8]1[CH2:14][N:13]2[CH2:15][CH:9]1[CH2:10][CH2:11][CH2:12]2)[C:6]#[N:7])[CH3:2]

Participants

5

Reactant 2

HCID 54463660HCID 54463660, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 10656658HCID 10656658, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of ethyl(1-azabicyclo[3.2.1]octan-6-ylidene)cyanoacetate (41 g, 0.19 mol) in abs. ethanol (500 ml) was treated with 10% palladium on carbon (5 g) and hydrogen in a Parr shaker at 30 psi for 5 h. Filtration and evaporation gave the title compound in 36 g yield.

Workup

  1. filtrationFiltration and evaporation

Sources & evidence

ORD record
ord-2ea49475eb2d444cbad6ec93c1524c39
Source dataset
uspto-grants-1998_01
Patent number
US05712271

Reaction notes

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