HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 727049Generated: October 29, 2026
Ammonia → 2,4-Diamino-6-chloro-5-(2,4-dichlorophenyl)-pyrimidine
https://huagongshe.com/reaction/727049
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 4,6-Dichloro-5-(2,4-dichlorophenyl)pyrimidin-2-amine | HCID 19705054 | — |
| Catalyst | Copper | HCID 23978 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2,4-Diamino-6-chloro-5-(2,4-dichlorophenyl)-pyrimidine | HCID 19705126 | 25% |
Reaction Steps
A mixture of 2-amino-5-(2,4-dichlorophenyl)-4,6-dichloropyrimidine (0.5 g) (Example 32) EtOH saturated with ammonia (20 ml) and copper powder (0.05 g) was heated in an autoclave at 180° C. for 18 hours. The cooled reaction mixture was filtered, evaporated and the residue purified by flash column chromatography to give the title compound (0.12, 25%), mp. 219° C. Microanalysis:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05712276 |
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| Source dataset | uspto-grants-1998_01 |
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| ORD ID | ord-301f9c92cce748aca502792bacc7dc21 |
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| Source note | uspto-grants-1998_01 |
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