HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,4-Diamino-5-(2,3-dichloro-4-nitrophenyl)-6-methylpyrimidine → 2,4-Diamino-5-(2,3,4-trichlorophenyl)-6-methylpyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,4-Diamino-5-(2,3-dichloro-4-nitrophenyl)-6-methylpyrimidine | HCID 19705031 | — |
| Reactant | Chloroform methanol | HCID 21584188 | — |
| Catalyst | Cuprous chloride | HCID 62652 | — |
| Product | 2,4-Diamino-5-(2,3,4-trichlorophenyl)-6-methylpyrimidine | HCID 19705056 | — |
Reaction Steps
This compound was made from the compound of Example 47 by reduction to the amine (PtO2, H2, AcOH), formation of the diazonium salt (NaNO2, H2SO4), and reaction of this with CuCl (as for Example 57). Sublimes at 275° C. Homogenous on TLC (methanol/chloroform, 1:9) Rf=0.36.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05712276 |
| Source dataset | uspto-grants-1998_01 |
| ORD ID | ord-38baae26d0734afcb327abdeb062fdb2 |
| Source note | uspto-grants-1998_01 |