HCID 54445383, compound → HCID 15379686, compound

HRID 727099Notes

Reaction equation

HRID 727099 reaction equation
[CH2:1]([O:3][C:4](=[O:16])[C:5](=[C:8]1[CH:13]2[CH2:14][CH2:15][N:10]([CH2:11][CH2:12]2)[CH2:9]1)[C:6]#[N:7])[CH3:2].[H][H]>C(O)C.[Pd]>[CH2:1]([O:3][C:4](=[O:16])[CH:5]([CH:8]1[CH:13]2[CH2:12][CH2:11][N:10]([CH2:15][CH2:14]2)[CH2:9]1)[C:6]#[N:7])[CH3:2]

Participants

5

Reactant 2

HCID 54445383HCID 54445383, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 15379686HCID 15379686, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of ethyl(1-azabicyclo[2.2.2]octan-3-ylidene)cyanoacetate (73 g, 0.33 mol) in absolute ethanol (1 l) was treated with 10% palladium on charcoal (10 g) and hydrogen in a parr shaker at 20 psi for 5 h. Filtration and evaporation gave the wanted product in 68 g yield.

Workup

  1. filtrationFiltration and evaporation
  2. customgave the wanted product in 68 g
  3. customyield

Sources & evidence

ORD record
ord-a8a9277cdecc4529984bfb4388ccb093
Source dataset
uspto-grants-1998_01
Patent number
US05712287

Reaction notes

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