Water → 4-(2,2,3,3-Tetrafluoro-2,3-dihydrobenzofuran-7-ylmethyl)cyclohexanone

HRID 727177Notes

Reaction equation

HRID 727177 reaction equation
[F:1][C:2]1([F:24])[C:6]([F:8])([F:7])[C:5]2[CH:9]=[CH:10][CH:11]=[C:12]([CH2:13][CH:14]3[CH2:23][CH2:22][C:17]4(OCC[O:18]4)[CH2:16][CH2:15]3)[C:4]=2[O:3]1.O>C(O)(=O)C>[F:24][C:2]1([F:1])[C:6]([F:7])([F:8])[C:5]2[CH:9]=[CH:10][CH:11]=[C:12]([CH2:13][CH:14]3[CH2:15][CH2:16][C:17](=[O:18])[CH2:22][CH2:23]3)[C:4]=2[O:3]1

Participants

4

Reactant 2

HCID 962WaterHCID 19705195HCID 19705195, compound

Product 1

HCID 197052664-(2,2,3,3-Tetrafluoro-2,3-dihydrobenzofuran-7-ylmethyl)cyclohexanone

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

This compound is prepared in a manner analogous to that of Step D of Example 2, using 6.2 grams (0.018 mole) of 8-(2,2,3,3-tetrafluoro-2,3-dihydrobenzofuran-7-ylmethyl)-1,4-dioxaspiro[4.5]decane and 25 mL of water in 100 mL of acetic acid, yielding 4-(2,2,3,3-tetrafluoro-2,3-dihydrobenzofuran-7-ylmethyl)cyclohexanone.

Workup

  1. customThis compound is prepared in a manner analogous to that of Step D of Example 2

Sources & evidence

ORD record
ord-2154205198ae48f49489dc56d61d7365
Source dataset
uspto-grants-1998_01
Patent number
US05712281

Reaction notes

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